Denis Le Bihan, M.D., Ph.D.

 






 

 

 

Scientific articles and reviews  (selection)
 (h-score: 60, citations > 11000 as of November 2007)
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         : Articles of special interest (click for an abstract when PDF is not available)

2007

  1. Nakamura K, Dehaene S, Jobert A, Le Bihan D, Kouider S. Task-specific change of unconscious neural priming in the cerebral language network. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19643-8.
  2. Pinel P, Thirion B, Meriaux S, Jobert A, Serres J, Le Bihan D, Poline JB, Dehaene S. Fast reproducible identification and large-scale databasing of individual functional cognitive networks. BMC Neurosci. 2007 Oct 31;8(1):91 [Epub ahead of print].
  3. Rodrigo S, Naggara O, Oppenheim C, Golestani N, Poupon C, Cointepas Y, Mangin JF, Le Bihan D, Meder JF. Human subinsular asymmetry studied by diffusion tensor imaging and fiber tracking. AJNR Am J Neuroradiol. 2007 Sep;28(8):1526-31.
  4. Kouider S, Dehaene S, Jobert A, Le Bihan D. Cerebral bases of subliminal and supraliminal priming during reading. Cereb Cortex. 2007 Sep;17(9):2019-29.
  5. Rodrigo S, Oppenheim C, Chassoux F, Golestani N, Cointepas Y, Poupon C, Semah F, Mangin JF, Le Bihan D, Meder JF. Uncinate fasciculus fiber tracking in mesial temporal lobe epilepsy. Initial findings. Eur Radiol. 2007 Jul;17(7):1663-8.
  6. Landmann C, Dehaene S, Pappata S, Jobert A, Bottlaender M, Roumenov D, Le Bihan D. Dynamics of prefrontal and cingulate activity during a reward-based logical deduction task. Cereb Cortex. 2007 Apr;17(4):749-59.
  7. Dubois J, Dehaene-Lambertz G, Perrin M, Mangin JF, Cointepas Y, Duchesnay E, Le Bihan D, Hertz-Pannier L. Asynchrony of the early maturation of white matter bundles in healthy infants: Quantitative landmarks revealed noninvasively by diffusion tensor imaging. Hum Brain Mapp. 2007 Feb 22;29(1):14-27.
  8. Le Bihan D. The Wet Mind: Water and Functional Neuroimaging. Phys. Med. Biol. 2007 R2 : R57-R90.  
  9. Sigman M, Jobert A, Le Bihan D, Dehaene S. Parsing a sequence of brain activations at psychological times using fMRI. Neuroimage. 2007 Apr 1;35(2):655-68.
  10. Golestani N, Molko N, Dehaene S, Le Bihan D, Pallier C. Brain structure predicts the learning of foreign speech sounds. Cereb Cortex. 2007 Mar;17(3):575-82.
  11. Piazza M, Pinel P, Le Bihan D, Dehaene S. A magnitude code common to numerosities and number symbols in human intraparietal cortex. Neuron. 2007 Jan 18;53(2):293-305.
  12. Rodrigo S, Oppenheim C, Chassoux F, Golestani N, Cointepas Y, Poupon C, Semah F, Mangin JF, Le Bihan D, Meder JF. Uncinate fasciculus fiber tracking in mesial temporal lobe epilepsy. Initial findings. Eur Radiol. 2007 Jan 12; [Epub ahead of print].

2006

  1. Le Bihan D, Poupon C, Amadon A, Lethimonnier F. Artifacts and pitfalls in diffusion MRI. J Magn Reson Imaging. 2006 Sep;24(3):478-88.
  2. Dubois J, Poupon C, Lethimonnier F, Le Bihan D. Optimized diffusion gradient orientation schemes for corrupted clinical DTI data sets. MAGMA. 2006 Aug;19(3):134-43.
  3. Thirion B, Duchesnay E, Hubbard E, Dubois J, Poline JB, Le Bihan D, Dehaene S. Inverse retinotopy: inferring the visual content of images from brain activation patterns. Neuroimage. 2006 Dec;33(4):1104-16.
  4. Le Bihan D. [From Brownian motion to mind imaging: diffusion MRI]. Bull Acad Natl Med. 2006 Nov;190(8):1605-27; discussion 1627. Review. French.
  5. Dehaene-Lambertz G, Dehaene S, Anton JL, Campagne A, Ciuciu P, Dehaene GP, Denghien I, Jobert A, Le Bihan D, Sigman M, Pallier C, Poline JB. Functional segregation of cortical language areas by sentence repetition. Hum Brain Mapp. 2006 May;27(5):360-71.
  6. Le Bihan D, Urayama S, Aso T, Hanakawa T, Fukuyama H. Direct and fast detection of neuronal activation in the human brain with diffusion MRI. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8263-8. Epub 2006 May 15.
  7. Golestani N, Alario FX, Meriaux S, Le Bihan D, Dehaene S, Pallier C. Syntax production in bilinguals. Neuropsychologia. 2006;44(7):1029-40.
  8. Dubois J, Hertz-Pannier L, Dehaene-Lambertz G, Cointepas Y, Le Bihan D. Assessment of the early organization and maturation of infants' cerebral white matter fiber bundles: A feasibility study using quantitative diffusion tensor imaging and tractography. Neuroimage. 2006 May 1;30(4):1121-32. Epub 2006 Jan 18.
  9. Dehaene-Lambertz G, Dehaene S, Anton JL, Campagne A, Ciuciu P, Dehaene GP, Denghien I, Jobert A, Le Bihan D, Sigman M, Pallier C, Poline JB. Functional segregation of cortical language areas by sentence repetition. Hum Brain Mapp. 2006 May;27(5):360-71. 

2005

  1. El Kouby V, Cointepas Y, Poupon C, Riviere D, Golestani N, Poline JB, Le Bihan D, Mangin JF. MR diffusion-based inference of a fiber bundle model from a population of subjects. Med Image Comput Comput Assist Interv Int Conf 2005;8(Pt 1):196-204. 
  2. Golestani N, Alario FX, Meriaux S, Le Bihan D, Dehaene S, Pallier C. Syntax production in bilinguals. Neuropsychologia. 2006;44(7):1029-40. Epub 2006 Jan 19. 
  3. Dodel S, Golestani N, Pallier C, Elkouby V, Le Bihan D, Poline JB. Condition-dependent functional  connectivity: syntax networks in bilinguals. Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):921-35. 
  4. Chabert S, Molko N, Cointepas Y, Le Roux P, Le Bihan D. Diffusion tensor imaging of the human optic nerve using a non-CPMG fast spin echo sequence. J Magn Reson Imaging. 2005 Aug;22(2):307-10. 
  5. Nakamura K, Dehaene S, Jobert A, Le Bihan D, Kouider S. Subliminal convergence of Kanji and Kana words: further evidence for functional parcellation of the posterior temporal cortex in visual word perception.
    J Cogn Neurosci. 2005 Jun;17(6):954-68. 
  6. Robert P, Violas X, Santus R, Le Bihan D, Corot C. Optimization of a blood pool contrast agent injection protocol for MR angiography. J Magn Reson Imaging. 2005 May;21(5):611-9. 
  7. Buffon F, Molko N, Herve D, Porcher R, Denghien I, Pappata S, Le Bihan D, Bousser MG, Chabriat H. Longitudinal diffusion changes in cerebral hemispheres after MCA infarcts. J Cereb Blood Flow Metab. 2005 May;25(5):641-50. 
  8. Perrin M, Poupon C, Rieul B, Leroux P, Constantinesco A, Mangin JF, Le Bihan D. Validation of q-ball imaging with a diffusion fibre-crossing phantom on a clinical scanner. Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):881-91. 
  9. Pouthas V, George N, Poline JB, Pfeuty M, Van de Moorteele PF, Hugueville L, Ferrandez AM, Lehericy S, Le Bihan D, Renault B. Neural network involved in time perception: an fMRI study comparing long and
    short interval estimation.     Hum Brain Mapp. 2005 Aug;25(4):433-41. 
  10. Herve D, Molko N, Pappata S, Buffon F, Le Bihan D, Bousser MG, Chabriat H. Longitudinal thalamic diffusion changes after middle cerebral artery infarcts. J Neurol Neurosurg Psychiatry. 2005 Feb;76(2):200-5. 

2004

  1. Klein I, Dubois J, Mangin JF, Kherif F, Flandin G, Poline JB, Denis M, Kosslyn SM, Le Bihan D. Retinotopic Organization of Visual Mental Images as Revealed by Functional Magnetic Resonance Imaging, Cogn.Brain.res. 2004; 22:26-31.  
  2. Committeri G, Galati G, Paradis AL, Pizzamiglio L, Berthoz A, Le Bihan D. Reference frames for spatial cognition: different brain areas are involved in viewer-, object-, and landmark-centered judgments about object location. J Cogn Neurosci. 2004 Nov;16(9):1517-35. 
  3. Gerardin E, Pochon JB, Poline JB, Tremblay L, Van de Moortele PF, Levy R, Dubois B, Le Bihan D, Lehericy S. Distinct striatal regions support movement selection, preparation and execution. Neuroreport. 2004 Oct 25;15(15):2327-31. 
  4. Cohen L, Jobert A, Le Bihan D, Dehaene S. Distinct unimodal and multimodal regions for word processing in the left temporal cortex. Neuroimage. 2004 Dec;23(4):1256-70. 
  5. Simon O, Kherif F, Flandin G, Poline JB, Riviere D, Mangin JF, Le Bihan D, Dehaene S. Automatized clustering and functional geometry of human parietofrontal networks for language, space, and number. Neuroimage. 2004 Nov;23(3):1192-1202. 
  6. Piazza M, Izard V, Pinel P, Le Bihan D, Dehaene S. Tuning curves for approximate numerosity in the human intraparietal sulcus. Neuron. 2004 Oct 28;44(3):547-55.
  7. Lehericy S, Gerardin E, Poline JB, Meunier S, Van de Moortele PF, Le Bihan D, Vidailhet M. Motor execution and imagination networks in post-stroke dystonia. Neuroreport. 2004 Aug 26;15(12):1887-90.
  8. Krainik A, Duffau H, Capelle L, Cornu P, Boch AL, Mangin JF, Le Bihan D, Marsault C, Chiras J, Lehericy S. Role of the healthy hemisphere in recovery after resection of the supplementary motor area. Neurology. 2004 Apr 27;62(8):1323-32.
  9. Dehaene S, Jobert A, Naccache L, Ciuciu P, Poline JB, Le Bihan D, Cohen L. Letter binding and invariant recognition of masked words: behavioral and neuroimaging evidence. Psychol Sci. 2004 May;15(5):307-13.
  10. Chainay H, Krainik A, Tanguy ML, Gerardin E, Le Bihan D, Lehericy S. Foot, face and hand representation in the human supplementary motor area. Neuroreport. 2004 Apr 9;15(5):765-9. 
  11. Molko N, Cachia A, Riviere D, Mangin JF, Bruandet M, Le Bihan D, Cohen L, Dehaene S. Brain anatomy in Turner syndrome: evidence for impaired social and spatial-numerical networks. Cereb Cortex. 2004 Aug;14(8):840-50. Epub 2004 Mar 28.
  12. Pinel P, Piazza M, Le Bihan D, Dehaene S. Distributed and overlapping cerebral representations of number, size, and luminance during comparative judgments. Neuron. 2004 Mar 25;41(6):983-93. 
  13. Mangin JF, Riviere D, Coulon O, Poupon C, Cachia A, Cointepas Y, Poline JB, Le Bihan D, Regis J, Papadopoulos-Orfanos D. Coordinate-based versus structural approaches to brain image analysis. Artif Intell Med. 2004 Feb;30(2):177-97. Review.

2003

  1. Lori NF, Conturo TE, Le Bihan D. Definition of displacement probability and diffusion time in q-space magnetic resonance measurements that use finite-duration diffusion-encoding gradients. J Magn Reson. 2003 Dec;165(2):185-95.  
  2. Molko N, Cachia A, Riviere D, Mangin JF, Bruandet M, Le Bihan D, Cohen L, Dehaene S. Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin. Neuron. 2003 Nov 13;40(4):847-58. 
  3. Jacquemot C, Pallier C, Le Bihan D, Dehaene S, Dupoux E. Phonological grammar shapes the auditory cortex: a functional magnetic resonance imaging study. J Neurosci. 2003 Oct 22;23(29):9541-6. 
  4. Piazza M, Giacomini E, Le Bihan D, Dehaene S. Single-trial classification of parallel pre-attentive and serial attentive processes using functional magnetic resonance imaging. Proc R Soc Lond B Biol Sci. 2003 Jun 22;270(1521):1237-45.
  5. Le Bihan D. Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci. 2003 Jun;4(6):469-80. Review.
  6. Krainik A, Lehericy S, Duffau H, Capelle L, Chainay H, Cornu P, Cohen L, Boch AL, Mangin JF, Le Bihan D, Marsault C. Postoperative speech disorder after medial frontal surgery: role of the supplementary motor area. Neurology. 2003 Feb 25;60(4):587-94. 
  7. Gerardin E, Lehericy S, Pochon JB, Tezenas du Montcel S, Mangin JF, Poupon F, Agid Y, Le Bihan D, Marsault C.  Foot, hand, face and eye representation in the human striatum. Cereb Cortex. 2003 Feb;13(2):162-9. 
  8. Pallier C, Dehaene S, Poline JB, LeBihan D, Argenti AM, Dupoux E, Mehler J.  Brain imaging of language plasticity in adopted adults: can a second language replace the first? Cereb Cortex. 2003 Feb;13(2):155-61. 

2002

  1. Mangin JF, Poupon C, Cointepas Y, Riviere D, Papadopoulos-Orfanos D, Clark CA, Regis J, Le Bihan D. A framework based on spin glass models for the inference of anatomical connectivity from diffusion-weighted MR data - a technical review. NMR Biomed. 2002 Nov-Dec;15(7-8):481-92. Review. 
  2. Le Bihan D, van Zijl P. From the diffusion coefficient to the diffusion tensor. NMR Biomed. 2002 Nov-Dec;15(7-8):431-4. 
  3. Molko N, Pappata S, Mangin JF, Poupon F, Le Bihan D, Bousser MG, Chabriat H. Monitoring disease progression in CADASIL with diffusion magnetic resonance imaging: a study with whole brain histogram analysis. Stroke. 2002 Dec;33(12):2902-8. 
  4. Dupont S, Samson Y, Van de Moortele PF, Samson S, Poline JB, Hasboun D, Le Bihan D, Baulac M. Bilateral hemispheric alteration of memory processes in right medial temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2002 Nov;73(5):478-85. 
  5. Mangin JF, Poupon C, Clark C, Le Bihan D, Bloch I. Distortion correction and robust tensor estimation for MR diffusion imaging. Med Image Anal. 2002 Sep;6(3):191-8. 
  6. Dupont S, Samson Y, Le Bihan D, Baulac M. Anatomy of verbal memory: a functional MRI study. Surg Radiol Anat. 2002 Feb;24(1):57-63. 
  7. Molko N, Cohen L, Mangin JF, Chochon F, Lehericy S, Le Bihan D, Dehaene S. Visualizing the neural bases of a disconnection syndrome with diffusion tensor imaging. J Cogn Neurosci. 2002 May 15;14(4):629-36. 
  8. Lehericy S, Biondi A, Sourour N, Vlaicu M, du Montcel ST, Cohen L, Vivas E, Capelle L, Faillot T, Casasco A, Le Bihan D, Marsault C. Arteriovenous brain malformations: is functional MR imaging reliable for studying language reorganization in patients? Initial observations. Radiology. 2002 Jun;223(3):672-82. (WEB)
  9. Pochon JB, Levy R, Fossati P, Lehericy S, Poline JB, Pillon B, Le Bihan D, Dubois B. The neural system that bridges reward and cognition in humans: an fMRI study. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5669-74. 
  10. Dehaene S, Le Clec'H G, Poline JB, Le Bihan D, Cohen L. The visual word form area: a prelexical representation of visual words in the fusiform gyrus. Neuroreport. 2002 Mar 4;13(3):321-5. 
  11. Hertz-Pannier L, Chiron C, Jambaque I, Renaux-Kieffer V, Van de Moortele PF, Delalande O, Fohlen M, Brunelle F, Le Bihan D. Late plasticity for language in a child's non-dominant hemisphere: a pre- and post-surgery fMRI study. Brain. 2002 Feb;125(Pt 2):361-72. 
  12. Simon O, Mangin JF, Cohen L, Le Bihan D, Dehaene S. Topographical layout of hand, eye, calculation, and language-related areas in the human parietal lobe. Neuron. 2002 Jan 31;33(3):475-87. 

2001

  1. Lobel E, Kahane P, Leonards U, Grosbras M, Lehericy S, Le Bihan D, Berthoz A. Localization of human frontal eye fields: anatomical and functional findings of functional magnetic resonance imaging and intracerebral electrical stimulation. J Neurosurg. 2001 Nov;95(5):804-15.
  2. Pinel P, Dehaene S, Riviere D, Le Bihan D. Modulation of parietal activation by semantic distance in a number comparison task. Neuroimage. 2001 Nov;14(5):1013-26.
  3. Dupont S, Samson Y, Van de Moortele PF, Samson S, Poline JB, Adam C, Lehericy S, Le Bihan D, Baulac M.  Delayed verbal memory retrieval: a functional MRI study in epileptic patients with structural lesions of the left medial temporal lobe. Neuroimage. 2001 Nov;14(5):995-1003. 
  4. Rohl L, Geday J, Ostergaard L, Simonsen CZ, Vestergaard-Poulsen P, Andersen G, Le Bihan D, Gyldensted C. Correlation between diffusion- and perfusion-weighted MRI and neurological deficit measured by the Scandinavian Stroke Scale and Barthel Index in hyperacute subcortical stroke (< or = 6 hours). Cerebrovasc Dis. 2001;12(3):203-13. 
  5. Sakoh M, Ostergaard L, Gjedde A, Rohl L, Vestergaard-Poulsen P, Smith DF, Le Bihan D, Sakaki S, Gyldensted C. Prediction of tissue survival after middle cerebral artery occlusion based on changes in the apparent diffusion of water. J Neurosurg. 2001 Sep;95(3):450-8.
  6. Krainik A, Lehericy S, Duffau H, Vlaicu M, Poupon F, Capelle L, Cornu P, Clemenceau S, Sahel M, Valery CA, Boch AL, Mangin JF, Le Bihan D, Marsault C. Role of the supplementary motor area in motor deficit following medial frontal lobe surgery. Neurology. 2001 Sep 11;57(5):871-8. 
  7. Grosbras MH, Leonards U, Lobel E, Poline JB, Le Bihan D, Berthoz A. Human cortical networks for new and familiar sequences of saccades. Cereb Cortex. 2001 Oct;11(10):936-45.
  8. Molko N, Pappata S, Mangin JF, Poupon C, Vahedi K, Jobert A, Le Bihan D, Bousser MG, Chabriat H. Diffusion tensor imaging study of subcortical gray matter in cadasil. Stroke. 2001 Sep;32(9):2049-54.
  9. Rohl L, Ostergaard L, Simonsen CZ, Vestergaard-Poulsen P, Andersen G, Sakoh M, Le Bihan D, Gyldensted C. Viability thresholds of ischemic penumbra of hyperacute stroke defined by perfusion-weighted MRI and apparent diffusion coefficient. Stroke. 2001 May;32(5):1140-6. 
  10. Paradis AL, Van de Moortele PF, Le Bihan D, Poline JB. Slice acquisition order and blood oxygenation level dependent frequency content: an event-related functional magnetic resonance imaging study. MAGMA. 2001 Oct;13(2):91-100. 
  11. Marsault C, Oppenheim C, Le Bihan D.  [Does diffusion and perfusion MRI modify the diagnosis and management of cerebral ischemic accidents?] Bull Acad Natl Med. 2000;184(8):1687-99; discussion 1699-701. Review. French. 
  12. Darquie A, Poline JB, Poupon C, Saint-Jalmes H, Le Bihan D. Transient decrease in water diffusion observed in human occipital cortex during visual stimulation. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9391-5.  (WEB)
  13. Durand E, van de Moortele PF, Pachot-Clouard M, Le Bihan D. Artifact due to B(0) fluctuations in fMRI: correction using the k-space central line. Magn Reson Med. 2001 Jul;46(1):198-201. 
  14. Peres M, Van De Moortele PF, Pierard C, Lehericy S, Satabin P, Le Bihan D, Guezennec CY. Functional magnetic resonance imaging of mental strategy in a simulated aviation performance task. Aviat Space Environ Med. 2000 Dec;71(12):1218-31. 
  15. Dehaene S, Naccache L, Cohen L, Le Bihan D, Mangin JF, Poline JB, Riviere D. Cerebral mechanisms of word masking and unconscious repetition priming. Nat Neurosci. 2001 Jul;4(7):752-8. 
  16. Hertz-Pannier L, Chiron C, Vera P, Van de Morteele PF, Kaminska A, Bourgeois M, Hollo A, Ville D, Cieuta C, Dulac O, Brunelle F, Le Bihan D. Functional imaging in the work-up of childhood epilepsy. Childs Nerv Syst. 2001 Apr;17(4-5):223-8. Review. 
  17. Cerf-Ducastel B, Van de Moortele PF, MacLeod P, Le Bihan D, Faurion A. Interaction of gustatory and lingual somatosensory perceptions at the cortical level in the human: a functional magnetic resonance imaging study. Chem Senses. 2001 May;26(4):371-83. (WEB)
  18. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging. 2001 Apr;13(4):534-46. Review. 
  19. Poupon C, Mangin J, Clark CA, Frouin V, Regis J, Le Bihan D, Bloch I. Towards inference of human brain connectivity from MR diffusion tensor data. Med Image Anal. 2001 Mar;5(1):1-15. 
  20. Pochon JB, Levy R, Poline JB, Crozier S, Lehericy S, Pillon B, Deweer B, Le Bihan D, Dubois B. The role of dorsolateral prefrontal cortex in the preparation of forthcoming actions: an fMRI study. Cereb Cortex. 2001 Mar;11(3):260-6. 
  21. Andrade A, Kherif F, Mangin JF, Worsley KJ, Paradis AL, Simon O, Dehaene S, Le Bihan D, Poline JB. Detection of fMRI activation using cortical surface mapping. Hum Brain Mapp. 2001 Feb;12(2):79-93. 

2000

  1. Klein I, Paradis AL, Poline JB, Kosslyn SM, Le Bihan D. Transient activity in the human calcarine cortex during visual-mental imagery: an event-related fMRI study. J Cogn Neurosci. 2000;12 Suppl 2:15-23. 
  2. Clark CA, Le Bihan D. Water diffusion compartmentation and anisotropy at high b values in the human brain. Magn Reson Med. 2000 Dec;44(6):852-9. 
  3. Gerardin E, Sirigu A, Lehericy S, Poline JB, Gaymard B, Marsault C, Agid Y, Le Bihan D. Partially overlapping neural networks for real and imagined hand movements. Cereb Cortex. 2000 Nov;10(11):1093-104. (WEB)
  4. Stanescu-Cosson R, Pinel P, van De Moortele PF, Le Bihan D, Cohen L, Dehaene S. Understanding dissociations in dyscalculia: a brain imaging study of the impact of number size on the cerebral networks for exact and approximate calculation. Brain. 2000 Nov;123 ( Pt 11):2240-55. 
  5. Hertz-Pannier L, Lehericy S, Cordoliani YS, Le Bihan D, Marsault C, Brunelle F. [Brain functional MRI: physiological, technical, and methodological bases, and clinical applications]. J Radiol. 2000 Jun;81(6 Suppl):731-3. French. 
  6. Le Clec'H G, Dehaene S, Cohen L, Mehler J, Dupoux E, Poline JB, Lehericy S, van de Moortele PF, Le Bihan D. Distinct cortical areas for names of numbers and body parts independent of language and input modality. Neuroimage. 2000 Oct;12(4):381-91. 
  7. Galati G, Lobel E, Vallar G, Berthoz A, Pizzamiglio L, Le Bihan D. The neural basis of egocentric and allocentric coding of space in humans: a functional magnetic resonance study. Exp Brain Res. 2000 Jul;133(2):156-64. 
  8. Hertz-Pannier L, Lehericy S, Cordoliani Y, Le Bihan D, Marsault C, Brunelle F. [Brain functional MRI: physiological, technical, and methodological bases, and clinical applications] J Radiol. 2000 Jun;81(6 Suppl):717-30. Review. French. 
  9. Chabriat H, Pappata S, Ostergaard L, Clark CA, Pachot-Clouard M, Vahedi K, Jobert A, Le Bihan D, Bousser MG. Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking. Stroke. 2000 Aug;31(8):1904-12. 
  10. Peres M, Van de Moortele PF, Pierard C, Lehericy S, Satabin P, Le Bihan, Guezennec CY. Functional magnetic resonance imaging of mental strategy in a simulated aviation performance task.  Aviat.Space.Environ.Med. 2000 71.(12.):1218-1231. (WEB)
  11. Paradis AL, Cornilleau-Peres V, Droulez J, Van De Moortele PF, Lobel E, Berthoz A, Le Bihan D, Poline JB. Visual perception of motion and 3-D structure from motion: an fMRI study. Cereb Cortex. 2000 Aug;10(8):772-83. 
  12. Poupon C, Clark CA, Frouin V, Regis J, Bloch I, Le Bihan D, Mangin J. Regularization of diffusion-based direction maps for the tracking of brain white matter fascicles. Neuroimage. 2000 Aug;12(2):184-95. 
  13. Dupont S, Van de Moortele PF, Samson S, Hasboun D, Poline JB, Adam C, Lehericy S, Le Bihan D, Samson Y, Baulac M. Episodic memory in left temporal lobe epilepsy: a functional MRI study. Brain. 2000 Aug;123 ( Pt 8):1722-32. 
  14. Le Bihan D. What to expect from MRI in the investigation of the central nervous system? C R Acad Sci III. 2000 Apr;323(4):341-50. Review. 
  15. Lehericy S, Cohen L, Bazin B, Samson S, Giacomini E, Rougetet R, Hertz-Pannier L, Le Bihan D, Marsault C, Baulac M. Functional MR evaluation of temporal and frontal language dominance compared with the Wada test. Neurology. 2000 Apr 25;54(8):1625-33. 
  16. Lehericy S, Duffau H, Cornu P, Capelle L, Pidoux B, Carpentier A, Auliac S, Clemenceau S, Sichez JP, Bitar A, Valery CA, Van Effenterre R, Faillot T, Srour A, Fohanno D, Philippon J, Le Bihan D, Marsault C.  Correspondence between functional magnetic resonance imaging somatotopy and individual brain anatomy of the central region: comparison with intraoperative stimulation in patients with brain tumors. J Neurosurg. 2000 Apr;92(4):589-98. 
  17. Bazin B, Cohen L, Lehericy S, Pierrot-Deseilligny C, Marsault C, Baulac M, Le Bihan D. [Study of hemispheric lateralization of language regions by functional MRI. Validation with the Wada test] Rev Neurol (Paris). 2000 Feb;156(2):145-8. French. 
  18. Chabriat H, Vahedi K, Clark CA, Poupon C, Ducros A, Denier C, Le Bihan D, Bousser MG. Decreased hemispheric water mobility in hemiplegic migraine related to mutation of CACNA1A gene. Neurology. 2000 Jan 25;54(2):510-2. 
  19. Gaillard WD, Hertz-Pannier L, Mott SH, Barnett AS, Le Bihan D, Theodore WH. Functional anatomy of cognitive development: fMRI of verbal fluency in children and adults. Neurology. 2000 Jan 11;54(1):180-5.

1999

  1. Faurion A, Cerf B, Van De Moortele PF, Lobel E, Mac Leod P, Le Bihan D. Human taste cortical areas studied with functional magnetic resonance imaging: evidence of functional lateralization related to handedness. Neurosci Lett. 1999 Dec 31;277(3):189-92. 
  2. Crozier S, Sirigu A, Lehericy S, van de Moortele PF, Pillon B, Grafman J, gid Y, Dubois B, LeBihan D. Distinct prefrontal activations in processing sequence at the sentence and script level: an fMRI study. Neuropsychologia. 1999 Dec;37(13):1469-76. 
  3. Chabriat H, Pappata S, Poupon C, Clark CA, Vahedi K, Poupon F, Mangin JF, Pachot-Clouard M, Jobert A, Le Bihan D, Bousser MG. Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI. Stroke. 1999 Dec;30(12):2637-43. 
  4. Grosbras MH, Lobel E, Van de Moortele PF, LeBihan D, Berthoz A. An anatomical landmark for the supplementary eye fields in human revealed with functional magnetic resonance imaging. Cereb Cortex. 1999 Oct-Nov;9(7):705-11. 
  5. Le Bihan D. [What to expect from MRi in the investigation of the central nervous system?] Bull Acad Natl Med. 1999;183(3):487-505; discussion 505-7. Review. French. 
  6. Pinel P, Le Clec'H G, van de Moortele PF, Naccache L, Le Bihan D, Dehaene S. Event-related fMRI analysis of the cerebral circuit for number comparison. Neuroreport. 1999 May 14;10(7):1473-9. 
  7. Lobel E, Kleine JF, Leroy-Willig A, Van de Moortele PF, Le Bihan D, Grusser OJ, Berthoz A. Cortical areas activated by bilateral galvanic vestibular stimulation. Ann N Y Acad Sci. 1999 May 28;871:313-23. 
  8. Lehericy S, Marsault C, Le Bihan D. [Functional MRI: brain plasticity, brain disease and functional recovery] J Neuroradiol. 1999 Mar;26(1 Suppl):S75-81. Review. French. 
  9. Le Bihan D, Lehericy S. [Practical aspects of realization of a functional MRI] J Neuroradiol. 1999 Mar;26(1Suppl):S54-8. Review. French. 
  10. Vallar G, Lobel E, Galati G, Berthoz A, Pizzamiglio L, Le Bihan D. A fronto-parietal system for computing the egocentric spatial frame of reference in humans. Exp Brain Res. 1999 Feb;124(3):281-6. 

1998

  1. Cerf B, Le Bihan D, Van de Moortele PF, Mac Leod P, Faurion A. Functional lateralization of human gustatory cortex related to handedness disclosed by fMRI study. Ann N Y Acad Sci. 1998 Nov 30;855:575-8. 
  2. Faurion A, Cerf B, Le Bihan D, Pillias AM. fMRI study of taste cortical areas in humans. Ann N Y Acad Sci. 1998 Nov 30;855:535-45. 
  3. Lobel E, Kleine JF, Le Bihan D, Leroy-Willig A, Berthoz A. Functional MRI of galvanic vestibular stimulation. J Neurophysiol. 1998 Nov;80(5):2699-709. (WEB)
  4. Le Bihan D. [Voir le cerveau penser : qu’attendre de l’imagerie fonctionnelle par IRM ?] Annales de l’Institut Pasteur 1998 9 : 75-82. French.
  5. Dehaene S, Le Clec'H G, Cohen L, Poline JB, van de Moortele PF, Le Bihan D. Inferring behavior from functional brain images. Nat Neurosci. 1998 Nov;1(7):549-50. 
  6. Dehaene S, Naccache L, Le Clec'H G, Koechlin E, Mueller M, Dehaene-Lambertz G, van de Moortele PF, Le Bihan D. Imaging unconscious semantic priming. Nature. 1998 Oct 8;395(6702):597-600. 
  7. Lehericy S, van de Moortele PF, Lobel E, Paradis AL, Vidailhet M, Frouin V, Neveu P, Agid Y, Marsault C, Le Bihan D.   Somatotopical organization of striatal activation during finger and toe movement: a 3-T functional magnetic resonance imaging study. Ann Neurol. 1998 Sep;44(3):398-404. 
  8. Le Bihan D. Differentiation of benign versus pathologic compression fractures with diffusion-weighted MR imaging: a closer step toward the "holy grail" of tissue characterization? Radiology. 1998 May;207(2):305-7. 

1997

  1. Van de Moortele PF, Cerf B, Lobel E, Paradis AL, Faurion A, Le Bihan D. Latencies in fMRI time-series: effect of slice acquisition order and perception. NMR Biomed. 1997 Jun-Aug;10(4-5):230-6. 
  2. Dehaene S, Dupoux E, Mehler J, Cohen L, Paulesu E, Perani D, van de Moortele PF, Lehericy S, Le Bihan D. Anatomical variability in the cortical representation of first and second language. Neuroreport. 1997 Dec 1;8(17):3809-15. 
  3. Le Bihan D. [MRI and cognition] Encephale. 1997 Jun;23 Spec No 3:5-8. Review. French. 
  4. Sadato N, Ibanez V, Campbell G, Deiber MP, Le Bihan D, Hallett M. Frequency-dependent changes of regional cerebral blood flow during finger movements: functional MRI compared to PET. J Cereb Blood Flow Metab. 1997 Jun;17(6):670-9. 
  5. Hertz-Pannler L, Le Bihan D. [Has functional cerebral MRI a clinical future?] J Radiol. 1997 Apr;78(4):263-4. French. 
  6. Hertz-Pannier L, Gaillard WD, Mott SH, Cuenod CA, Bookheimer SY, Weinstein S, Conry J, Papero PH, Schiff SJ, Le Bihan D, Theodore WH. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology. 1997 Apr;48(4):1003-12. 
  7. Mattiello J, Basser PJ, Le Bihan D. The b matrix in diffusion tensor echo-planar imaging. Magn Reson Med. 1997 Feb;37(2):292-300. 

1996

  1. Yang QX, Posse S, Le Bihan D, Smith MB. Double-sampled echo-planar imaging at 3 tesla. J Magn Reson B. 1996 Nov;113(2):145-50. 
  2. Berry I, Benderbous S, Ranjeva JP, Gracia-Meavilla D, Manelfe C, Le Bihan D. Contribution of Sinerem used as blood-pool contrast agent: detection of cerebral blood volume changes during apnea in the rabbit. Magn Reson Med. 1996 Sep;36(3):415-9. 
  3. Rueckert L, Lange N, Partiot A, Appollonio I, Litvan I, Le Bihan D, Grafman J. Visualizing cortical activation during mental calculation with functional MRI. Neuroimage. 1996 Apr;3(2):97-103.
  4. Le Bihan D. Functional MRI of the brain principles, applications and limitations. J Neuroradiol. 1996 Jun;23(1):1-5. Review. 
  5. Bizzi A, Righini A, Turner R, Le Bihan D, Bockhorst KH, Alger JR. Imaging focal reperfusion injury following global ischemia with diffusion-weighted magnetic resonance imaging and 1H-magnetic resonance spectroscopy. Magn Reson Imaging. 1996;14(6):581-92. 

1995

  1. Le Bihan D. Molecular diffusion, tissue microdynamics and microstructure. NMR Biomed. 1995 Nov-Dec;8(7-8):375-86. Review. 
  2. Cuenod CA, Bookheimer SY, Hertz-Pannier L, Zeffiro TA, Theodore WH, Le Bihan D. Functional MRI during word generation, using conventional equipment: a potential tool for language localization in the clinical environment. Neurology. 1995 Oct;45(10):1821-7. 
  3. Levy LM, Gulya AJ, Davis SW, Le Bihan D, Rajan SS, Schellinger D. Flow-sensitive magnetic resonance imaging in the evaluation of cerebrospinal fluid leaks. Am J Otol. 1995 Sep;16(5):591-6. 
  4. Leonardo M, Fieldman JB, Sadato R, Campbell G, Ibanez V, Cohen LG, Beiber MP, Pons T, Turner R, Le Bihan D, Hallett M. A Magnetic Resonance Functional Neuroimaging Study of Cortical Regions Associated with Motor Task Execution and Motor Ideation in Humans. Human Brain Mapping 1995 3::83-92.
  5. Hertz-Panier L, Cuenod CA, Posse S, Jezzard P, Prinster A, Turner R, Le Bihan D. Brain Functional Imaging at 1.5T: Feasibility and Comparison between Conventional Gradient Echo Sequences and Echo-Planar Imaging. Revue d'Imagerie Medicale 1995 7:13-20. English, French.
  6. Hertz-Pannier P, Le Bihan D. [Imagerie fonctionnelle cérébrale par IRM: Intérêt potentiel pour les tumeurs cérébrales de l'enfant.] Neuro-psy 1995 10:48-55. French.
  7. Le Bihan D. [IRM de la diffusion, de la perfusion et de la fonction cérébrale.] Journal des maladies vasculaires 1995 20;203-208. French.
  8. Le Bihan D, Mattiello J, Levin RL. Noninvasive Temperature Imaging by MRI: A review. Biomedical Thermology 1995 13:25-41. Review.
  9. Le Bihan D, Karni A. Applications of magnetic resonance imaging to the study of human brain function. Curr Opin Neurobiol. 1995 Apr;5(2):231-7. Review. 
  10. Le Bihan D, Jezzard P, Haxby J, Sadato N, Rueckert L, Mattay V. Functional magnetic resonance imaging of the brain. Ann Intern Med. 1995 Feb 15;122(4):296-303. Review. 
  11. Posse S, Cuenod CA, Risinger R, Le Bihan D, Balaban RS. Anomalous transverse relaxation in 1H spectroscopy in human brain at 4 Tesla. Magn Reson Med. 1995 Feb;33(2):246-52. 
  12. Le Bihan D. [Diffusion, perfusion and functional magnetic resonance imaging.] J Mal Vasc. 1995;20(3):203-14. English, French. 
  13. Posse S, Tedeschi G, Risinger R, Ogg R, Le Bihan D.  High speed 1H spectroscopic imaging in human brain by echo planar spatial-spectral encoding. Magn Reson Med. 1995 Jan;33(1):34-40. 

1994

  1. Posse S, De Carli C, Le Bihan D. Three-dimensional echo-planar MR spectroscopic imaging at short echo times in the human brain. Radiology. 1994 Sep;192(3):733-8. 
  2. Rueckert L, Appollonio I, Grafman J, Jezzard P, Johnson R Jr, Le Bihan D, Turner R. Magnetic resonance imaging functional activation of left frontal cortex during covert word production. J Neuroimaging. 1994 Apr;4(2):67-70. 
  3. Koizumi H, Le Bihan D. [Present Status and Future of Functional Magnetic Resonance Imaging.] Innervision 1994 12:14-19. Japanese.
  4. Mattiello J, Basser P.J., Le Bihan D. Analytical Expressions for the b Matrix in NMR Diffusion Imaging and Spectroscopy. J. Magn. Reson., Series A, 1994 108:131-141.
  5. Basser PJ, Mattiello J, LeBihan D. Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B. 1994 Mar;103(3):247-54. 
  6. Basser PJ, Mattiello J, LeBihan D. MR diffusion tensor spectroscopy and imaging. Biophys J. 1994 Jan;66(1):259-67. 

1993

  1. Le Bihan D, Turner R, Zeffiro TA, Cuenod CA, Jezzard P, Bonnerot V. Activation of human primary visual cortex during visual recall: a magnetic resonance imaging study. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11802-5.
  2. Bizzi A, Righini A, Turner R, Le Bihan D, DesPres D, Di Chiro G, Alger JR. MR of diffusion slowing in global cerebral ischemia. AJNR Am J Neuroradiol. 1993 Nov-Dec;14(6):1347-54. 
  3. Posse S, Cuenod CA, Le Bihan D. Human brain: proton diffusion MR spectroscopy. Radiology. 1993 Sep;188(3):719-25. 
  4. Posse S, Cuenod CA, Le Bihan D. Motion artifact compensation in 1H spectroscopic imaging by signal tracking. J. Mag. Reson. Series B 1993 102:222-227. 
  5. Le Bihan D, Turner R, Douek P. Is water diffusion restricted in human brain white matter? An echo-planar NMR imaging study. Neuroreport. 1993 Jul;4(7):887-90. 
  6. Davis SW, Levy LM, Le Bihan D, Rajan S, Schellinger D. Sacral meningeal cysts: evaluation with MR imaging. Radiology. 1993 May;187(2):445-8. 
  7. Le Bihan D. MRI: [New Developments in Functional Imaging of the Brain.] Human Imaging 1993 16:10-12. Japanese.
  8. Turner R, Jezzard P, Wen H, Kwong KK, Le Bihan D, Zeffiro T, Balaban RS. Functional mapping of the human visual cortex at 4 and 1.5 tesla using deoxygenation contrast EPI. Magn Reson Med. 1993 Feb;29(2):277-9. 
  9. Le Bihan D, Douek P, Argyropoulou M, Turner R, Patronas N, Fulham M. Diffusion and perfusion magnetic resonance imaging in brain tumors. Top Magn Reson Imaging. 1993 5(1):25-31. Review. 

1992

  1. Le Bihan D. Theoretical principles of perfusion imaging. Application to magnetic resonance imaging. Invest Radiol. 1992 Dec;27 Suppl 2:S6-11. Review. 
  2. Le Bihan D, Turner R, Douek P, Patronas N. Diffusion MR imaging: clinical applications. AJR Am J Roentgenol. 1992 Sep;159(3):591-9. Review. 
  3. Le Bihan D, Turner R. The capillary network: a link between IVIM and classical perfusion. Magn Reson Med. 1992 Sep;27(1):171-8. Review. 
  4. Schellinger D, Le Bihan D, Rajan SS, Cammarata CA, Patronas NJ, Deveikis JP, Levy LM. MR of slow CSF flow in the spine. AJNR Am J Neuroradiol. 1992 Sep-Oct;13(5):1393-403. 
  5. Zhang Y, Samulski TV, Joines WT, Mattiello J, Levin RL, Le Bihan D. On the accuracy of noninvasive thermometry using molecular diffusion magnetic resonance imaging. Int J Hyperthermia. 1992 Mar-Apr;8(2):263-74. 

1991

  1. Douek P, Turner R, Pekar J, Patronas N, Le Bihan D. MR color mapping of myelin fiber orientation. J Comput Assist Tomogr. 1991 Nov-Dec;15(6):923-9. 
  2. Turner R, Le Bihan D, Moonen CT, Despres D, Frank J. Echo-planar time course MRI of cat brain oxygenation changes. Magn Reson Med. 1991 Nov;22(1):159-66. 
  3. Delannoy J, Chen CN, Turner R, Levin RL, Le Bihan D. Noninvasive temperature imaging using diffusion MRI. Magn Reson Med. 1991 Jun;19(2):333-9. 
  4. Turner R, Le Bihan D, Chesnick AS. Echo-planar imaging of diffusion and perfusion. Magn Reson Med. 1991 Jun;19(2):247-53. Review. 
  5. Le Bihan D, Turner R. Intravoxel incoherent motion imaging using spin echoes. Magn Reson Med. 1991 Jun;19(2):221-7. Review. 
  6. Le Bihan D. Molecular diffusion nuclear magnetic resonance imaging. Magn Reson Q. 1991 Jan;7(1):1-30. Review.
  7. Le Bihan D, Moonen CT, van Zijl PC, Pekar J, DesPres D. Measuring random microscopic motion of water in tissues with MR imaging: a cat brain study. J Comput Assist Tomogr. 1991 Jan-Feb;15(1):19-25. 
  8. Le Bihan D, Turner R, Moonen CT, Pekar J. Imaging of diffusion and microcirculation with gradient sensitization: design, strategy, and significance. J Magn Reson Imaging. 1991 Jan-Feb;1(1):7-28. Review.  

1990-1987

  1. Turner R, Le Bihan D, Maier J, Vavrek R, Hedges LK, Pekar J. Echo-planar imaging of intravoxel incoherent motion. Radiology. 1990 Nov;177(2):407-14.  
  2. Turner R, Le Bihan D. Single-shot Diffusion Imaging at 2.0 Teslas. J. Magn.Reson. 1990 86:445-52.  
  3. Le Bihan D. Diffusion/perfusion MR imaging of the brain: from structure to function. Radiology. 1990 Nov;177(2):328-9. 
  4. Moonen CT, van Zijl PC, Frank JA, Le Bihan D, Becker ED. Functional magnetic resonance imaging in medicine and physiology. Science. 1990 Oct 5;250(4977):53-61. Review. 
  5. Delannoy J, Le Bihan D, Hoult DI, Levin RL. Hyperthermia system combined with a magnetic resonance imaging unit. Med Phys. 1990 Sep-Oct;17(5):855-60. 
  6. Le Bihan D. IVIM method measures diffusion and perfusion. Diagn Imaging (San Franc). 1990 Jun;12(6):133, 136. 
  7. Le Bihan D. Magnetic resonance imaging of perfusion. Magn Reson Med. 1990 May;14(2):283-92. 
  8. Moonen CT, van Zijl PC, Le Bihan D, DesPres D. In vivo NMR diffusion spectroscopy: 31P application to phosphorus metabolites in muscle. Magn Reson Med. 1990 Mar;13(3):467-77. 
  9. Le Bihan D, Turner R, MacFall JR. Effects of intravoxel incoherent motions (IVIM) in steady-state free precession (SSFP) imaging: application to molecular diffusion imaging. Magn Reson Med. 1989 Jun;10(3):324-37. 
  10. Le Bihan D, Delannoy J, Levin RL. Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia. Radiology. 1989 Jun;171(3):853-7. 
  11. Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology. 1988 Aug;168(2):497-505. 
  12. Le Bihan D. Intravoxel incoherent motion imaging using steady-state free precession. Magn Reson Med. 1988 Jul;7(3):346-51.  
  13. Le Bihan D, Breton E, Aubin ML, Lallemand D, Vignaud J. Study of cerebrospinal fluid dynamics by MRI of intravoxel incoherent motions (IVIM). J Neuroradiol. 1987;14(4):388-95. English, French. 
  14. Le Bihan D, Breton E, Lallemand D, Desbleds MT, Aubin ML, Vignaud J, Roger B. Contribution of intravoxel incoherent motion (IVIM) imaging to neuroradiology. J Neuroradiol. 1987;14(4):295-312. English, French. 

1986-1982

  1. Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986 Nov;161(2):401-7. 
  2. Cavezian R, Cabanis EA, Pasquet G, Iba-Zizen MT, Le Bihan D, Tamraz J, Roger B.  [Magnetic resonance imaging. Physical principles, current biomedical applications, maxillofacial perspectives] Actual Odontostomatol (Paris). 1986 Jun;40(154):219-32. French. 
  3. Bregeat P, Cabanis EA, Iba-Zizen MT, Tamraz J, Stoffels C, Alfonso JM, Lopez A, Le Bihan D. [Optic nerve and magnetic resonance] Bull Soc Ophtalmol Fr. 1986 May;86(5):627-31. French. 
  4. Cabanis EA, Iba-Zizen MT, Stoffels C, Tamraz J, Aubin ML, Cosnard G, Le Bihan D. [Magnetic resonance imaging of the head compared with the CT scan] Arch Int Physiol Biochim. 1985 Dec;93(5):27-34. French.
  5. Le Bihan D, Breton E. [Imagerie de diffusion in-vivo par résonance magnétique nucléaire], C R Acad Sci (Paris) 301,15, 1109-1112,1985. French.
  6. Le Bihan D. [Microcomputer simulation of nuclear magnetic resonance imaging contrasts] J Radiol. 1985 Apr;66(4):303-8. French. 
  7. Pasquet G, Cabanis EA, Cavezian R, Iba Zizen MT, Le Bihan D, Salvolini U. [Modern medical imaging] Actual Odontostomatol (Paris). 1984 Dec;38(148):605-17. French. 
  8. Le Bihan D, Gambini D., Granier R., Leterrier F. [Applications biomédicales de la résonance magnétique], Revue Fr. Lab. 1983:118-130. French.
  9. Le Bihan D. [La Résonance Magnétique Nucléaire: Principes et Résultats] La Revue de Médecine 1982 34:1783-1788. French. 
  10. Cabanis EA, Le Bihan D, Frija G, Bismuth V, Gaux JC. [1981 : digital angiography by the intravenous route. 1982 : nuclear magnetic resonance] Bull Soc Ophtalmol Fr. 1982 Jun-Jul;82(6-7):801-7. French. 

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